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Trimethoprim(an anti-bacterial drug) and methotrexate(MTX, an anti-cancer drug)

binds to DHFR much easier than folate.
Therefore, analogues of trimethoprim and methotrexate becomes
good candiates for binding tests.



科普導讀：天下文化所出版《基因聖戰》（Jerry Bishop 著，楊玉齡 譯），1994, 10


Where to dotain the molecules?
from Brookheaven Protein Databank(US. $70, one CD)

available from ftp.csie.ntu.edu.tw(台大資訊系), including Xray, CT, MRI,
Ultrasound data.